Associations of pre-existing cardiovascular morbidity with severity and the fatality rate in COVID-19 patients: a systematic review and meta-analysis

Associations of pre-existing cardiovascular morbidity with severity and the fatality rate in COVID-19 patients: a systematic review and meta-analysis

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Objectives The aim of this study was to evaluate the association of pre-existing cardiovascular comorbidities, including hypertension and coronary heart disease, with coronavirus disease 2019 (COVID-19) severity and mortality.Methods PubMed, ScienceDirect, and Scopus were searched between January 1, 2020, and July 18, 2020, to identify eligible studies.Random-effect models were used to estimate the pooled event rates of pre-existing cardiovascular disease comorbidities and odds ratio (OR) with 95% confidence intervals (95% CIs) of disease severity and mortality associated with the exposures of interest.Results A total of 34 studies involving 19,156 patients with COVID-19 infection met hindigyanvishv.com the inclusion criteria.

The prevalence of pre-existing cardiovascular disease in the included studies was 14.0%.Pre-existing cardiovascular disease in COVID-19 patients was associated with severe outcomes (OR, 4.1; 95% CI, 2.

9 to 5.7) and mortality (OR, 6.1; 95% CI, 2.9 to 12.

7).Hypertension and coronary heart disease increased the risk of severe outcomes by 3 times ealisboa.com (OR, 3.2; 95% CI, 2.0 to 3.

6) and 2.5 times (OR, 2.5; 95% CI, 1.7 to 3.

8), respectively.No significant publication bias was indicated.Conclusion COVID-19 patients with pre-existing cardiovascular comorbidities have a higher risk of severe outcomes and mortality.Awareness of pre-existing cardiovascular comorbidity is important for the early management of COVID-19.